Does caffeine influence insulin sensitivity?

By Rebecca Israel, MS. Reviewed by Charles Li, MD

July 02, 2020

  • Multiple studies have seen decreases in insulin sensitivity due to caffeine consumption.

  • A study found a positive association between coffee and increased insulin sensitivity.

  • Benefits to insulin must be a result of something else in the coffee, not the caffeine.

caffeine and insulin title

Insulin is a hormone that regulates glucose, or sugar, in the blood. Insulin sensitivity allows the body to use blood glucose effectively. Insulin resistance is when the body can not properly use blood glucose. The levels of sensitivity and resistance are influenced by health behaviors like weight loss and diet.

Influence of caffeine

Researchers systematically reviewed nine trials with 134 participants that measured caffeine and insulin sensitivity. Particularly, they looked at studies of type-2 diabetes patients.

insulin sensitivity index was 14% to 37% lower (P  = 0.02) in the caffeine trial compared to placebo

Source: Systematic review of randomized controlled trials of the effects of caffeine or caffeinated drinks on blood glucose concentrations and insulin sensitivity in people with diabetes mellitus

Participants who were given caffeine had a lower insulin sensitivity index than those in the placebo group. This means that caffeine can inhibit the body’s ability to use blood glucose effectively.

More Information on Caffeine

Coffee as a caffeine source

What is the association between coffee consumption and insulin sensitivity?

Source: Coffee Consumption and Insulin Sensitivity

To see how coffee influences insulin, data were reanalyzed from the Uppsala Longitudinal Study of Adult Men where participants were instructed to keep logs of their dietary habits and other behaviors.

A 1-cup increase of coffee per day was associated with 0.16-units higher insulin sensitivity.

Researchers considered other factors that may influence insulin sensitivity such as sugar, cream, pastries, and smoking status. With these factors considered, they found that a 1-cup increase of coffee per day was associated with 0.16-units higher insulin sensitivity. They also found significant associations between insulin sensitivity, sugar intake, and body mass index.

How can caffeine decrease insulin sensitivity while coffee increases it? Well, the insulin benefit must be coming from a different source in the coffee.

It is possible that antioxidants in coffee could improve insulin sensitivity, given that insulin sensitivity has been reported to be associated with the activity of antioxidants.

JAMA

Overall, these studies are particularly useful for those with diabetes. Caffeine on its own and added sugar were associated with decreased insulin sensitivity. This information is useful for diet management, along with maintaining a relationship with doctors and nutritionists.

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